Buffalo kicked off its 2022 campaign with dominance, with MVP favorite Josh Allen leading the high-flying Bills past the reigning-champion Rams. The Titans served as one of the many favorites to get upset in Week 1, falling to a Giants squad that won just four games total all of last season. Now Buffalo welcomes Tenne see for its 2022 home-opener, one of the two Monday Night Football games this week (this one's on ESPN, while Vikings-Eagles will be on ABC). We have all the betting information, tips, storylines, and predictions for this star-studded affair.Not surprisingly, the Bills came out firing against the Rams last Thursday. Their offense looks largely the same as last season, with veteran wideout Jamison Crowder and rookie running back James Cook as the only major additions. Stefon Diggs and Gabe Davis picked up where they left Justin Herron Jersey off last postseason, combining for 12 catches, 210 yards, and two TDs. Despite a pair of interceptions, Allen finished with four total TDs and three yards shy of 300 yards.As for the Titans, they produced a handful of chunk-yardage plays, including a 23-yard catch-and-run for RB Dontrell Hilliard, one of his two scores on the day, but they never established a consistent line of attack. Tenne see's young receiving corps suffered from multiple cases of the dropsies, and two-time rushing champ Derrick Henry mounted a pedestrian (for him) 82 yards on the ground.WEEK 2 NFL BETTING: | | Will the Bills maintain their status as Super Bowl favorites this week? Or, will the underdog Titans bounce back from an underwhelming opener to deliver the upset? Let's dig into this one, analyze the betting trends,and find Tre Nixon Jersey all the betting angles to attack this weekend.Here's everything to know about wagering on Bills vs. Titans, including updated odds, trends, storylines, and our prediction.LIVE: Betting odds from Sports InteractionSpread: Bills -10Over/under:O 47.5(-110) | U 47.5(-110)Moneyline:Bills -458| Titans +370The Bills enter as ma sive favorites, one of the biggest spreads and moneylines of the NFL's first two weeks. The spread hovered between -7.5 and -9 last week but shot up to double-digits after Buffalo's ma sive win over the Rams and Tenne see's upset lo s to the Giants. The over/under has crawled down from 51 to 49. According to , the vast majority of action seems to be on the OVER, with a slight edge going to Buffalo -10 (56 percent of money, 65 percent of tickets).Take advantage ofand see all of our best bets acro s all sports, including college football, NFL and MLB!Tenne see leads the all-time series between the Titans and Bills 30-19 and has taken the last two matchups dating back to a 42-16 bludgeoning in October 2020. Henry scored two TDs in that battle, and he also scored the game-winning TD in Tenne see's 34-31 win last season. The Bills won the previous three meetings between these organizations going back to '15, while the Titans dominated the matchup 8-1 between 1995 and '12.Buffalo went 10-7-2 against the spread last season and 5-3-2 ATS at home. Tenne see went 3-3 ATS on the road but 3-2 ATS as road underdogs.Since December 2016, the Bills have gone 6-2-2 ATS in games they are favored to win by double-digits.The Titans have now lost four of their past five games without stud receiver A.J. Brown, who was traded to the Eagles in Jakob Johnson Jersey the offseason.Can the Titans secondary slow down the Bills receiving corps?While Tenne see limited Giants QB Daniel Jones to just 188 pa sing yards in Week 1, Mike Vrabel's secondary still allowed two pa sing TDs, including a 65-yard catch-and-run by Sterling Shepard. The Bills feature so many monsters on offense that Vrabel and defensive coordinator Shane Bowen might already be having nightmares. With a young trio of cornerbacks, all of whom were drafted in 2020 or later, we wonder if Buffalo will gash Tenne see through the air like it did when these teams met last October. In that contest, three different Bills receivers (Diggs, Emmanuel Sanders, and Cole Beasley) tallied at least five catches and 88-plus yards.Will Derrick Henry return to dominance and put the Titans on his back?Not surprisingly, Henry and Brown served as the main culprits in Tenne see's 34-31 win over Buffalo last fall, with Henry racking up 143 ground yards and two TDs and Brown ama sing seven catches for 91 yards. With Brown a distant memory, King Henry must return to the dominance he displayed prior to breaking his foot midway through last season. It's very early, but Titans fans can't be too optimistic after Week 1. Henry averaged just 3.9 yards per carry against a Giants squad that surrendered 4 Drew Desjarlais Jersey .5 yards per opponent carry last season.Now the two-time rushing champ must do battle with a Bills squad that allowed just 85.1 yards per game to RBs in 2021 and held the Rams to 52 ground yards in Week 1.Who will step up as Tenne see's leading receiver?Brown left a ma sive void in the Titans' pa sing attack, leaving behind nearly 3,000 regular-season receiving yards and 24 TDs in three seasons with Tenne see. The hope from within the organization was that first-round pick Treylon Burks, acquired in the Brown trade with Philly, would be able to immediately produce for the Titans mumblings out of training camp alluded to Burks not adapting quickly enough to the playbook, which felt all but verified in Week 1 with Burks seeing just 40 percent of Tenne see's offensive snaps and 15 percent of Ryan Tannehill's targets. The rookie did haul in three of those five targets for 55 yards, but 27 of those came from one play against busted coverage. A receiving corps featuring Burks, Kyle Philips, Nick Westbrook-Ikhine, and a dinged-up Robert Woods could have trouble against the Bills secondary, which as No. 6 in the NFL this Dalton Keene Jersey preseason.4-9.That's Tenne see's record in games that Derrick Henry logs 82 rushing yards or fewer, dating back to the start of the 2019 season. The Bills held Rams starter Darrell Henderson to 47 yards last Thursday and held teams to 80 or fewer total rushing yards nine different times last season.Make this one of your contenders for a Survivor Pool pick (if you're still alive, that is) because the Bills will absolutely not blow this one. The question obviously then becomes 'Will Buffalo cover the 10-point spread?' Most bettors shy away from double-digit favorites, but the Bills seem pretty safe this week. They have a strong secondary as well as a potent rushing defense, and Ram-turned-Bill edge rusher Von Miller has produced immediate dividends on the defensive line. With Tenne see sporting a young wide receiver corps and an even younger crop of cornerbacks, we're going with Buffalo to pull off the big win to the delight of Bills Mafia in the home-opener.PREDICTION: Bills 33, Titans 17. Buffalo covers (-10) and the game goes OVER (49).